Clostridium difficile Infection Risk Factors and Outcomes Among Inpatients Infected with NAP1/BI/027 Strain Compared to Non-NAP1 Strain in a Major Chinese Hospital

Background: NAP1/027 Clostridium difficile infection (CDI) has rarely been reported in China. Objectives: The objective of this study was to strengthen the understanding risk factors and outcomes CDI. Methods: A single-center, retrospective, case-control (1: 3) performed identify specific CDI using a group patients with (n = 20) age-matched control non-NAP1/027 60) within June 2018 August 2021. patient charts were thoroughly reviewed assess markers severity, factors, outcomes. Results: Out 272 stool specimens, 41 cases (15.07%) tested positive for NAP1 strain C. polymerase chain reaction. Among these 20 fulfilled inclusion criteria. No significant difference observed between groups disease length hospital stay, or mortality. Logistic regression analysis revealed that acquiring included hospitalization 90 days before diagnosis high C-reactive protein level ± 3 detection. Conclusions: In large non-epidemic tertiary China, strains more prevalent previous CRP than strains.